Question:

Correctly arrange the below given Transcription Factors (TFs) as per their involvement in initiation of eukaryotic transcription:

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Mnemonic: “Dog (D) Barks (B) For (F) Every (E) Human (H)” to remember the binding order.
Updated On: May 28, 2026
  • A, B, C, D and E
  • A, C, B, D and E
  • B, A, D, C and E
  • B, C, D, E and A
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The Correct Option is C

Solution and Explanation

Step 1: Concept
Initiation of eukaryotic transcription requires assembly of a Pre-Initiation Complex (PIC). Step 2--3: Analysis
TFIID (B) binds the TATA box first, followed by TFIIB (A). TFIIF (D) brings RNA Pol II. Finally TFIIE (C) and TFIIH (E) join to complete the complex.

Step 4: Conclusion

The assembly order is TFIID $\to$ TFIIB $\to$ TFIIF $\to$ TFIIE $\to$ TFIIH.

Final Answer: (C)
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