Step 1: Understanding the Concept
Different digestive enzymes need different pH conditions and are activated by different agents.
Step 2: Check the statements
Pepsin works at about pH 2 in the stomach, so A is correct. Trypsin works in the alkaline small intestine, so B is wrong.
Step 3: Check activation and control
Pepsinogen is activated by HCl, while enterokinase activates trypsinogen, so C is wrong. Gastric juice is stimulated by gastrin, not secretin, so D is wrong.
Final Answer:
The correct statement is that pepsin acts on proteins in an acidic medium.
\[ \boxed{\text{(A) }\text{Pepsin acts on protein in acidic medium.}} \]