Question:
Which of the following is true about the different structures of protein?
Which of the following is true about the different structures of protein?
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The sequence written first decides every fold that follows.
Updated On: Jun 23, 2026
- Secondary structure is the three-dimensional structure of protein
- Secondary structure is stabilized by disulfide bonds
- Primary, secondary and tertiary structures are destroyed during denaturation
- Secondary and tertiary structure depend on the sequence of amino acids
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The Correct Option is D
Solution and Explanation
Step 1: Recall the four levels of protein structure. Primary is the amino acid sequence. Secondary is local regular folding (alpha-helix, beta-sheet, beta-turn). Tertiary is the overall three-dimensional shape of one chain. Quaternary needs more than one chain.
Step 2: The primary sequence dictates how the chain folds, so both secondary and tertiary structures are ultimately determined by the amino acid sequence. That makes option (d) correct.
Step 3: Why the others fail: (a) the three-dimensional shape of one chain is tertiary, not secondary. (b) disulfide bonds stabilize tertiary (and quaternary) structure, not secondary, which is held by backbone hydrogen bonds. (c) denaturation unfolds secondary and tertiary structure but does NOT break peptide bonds, so the primary structure is preserved.
Ref: Lippincott's Illustrated Reviews Biochemistry, 5e, Structure of Proteins, p 13.
Step 2: The primary sequence dictates how the chain folds, so both secondary and tertiary structures are ultimately determined by the amino acid sequence. That makes option (d) correct.
Step 3: Why the others fail: (a) the three-dimensional shape of one chain is tertiary, not secondary. (b) disulfide bonds stabilize tertiary (and quaternary) structure, not secondary, which is held by backbone hydrogen bonds. (c) denaturation unfolds secondary and tertiary structure but does NOT break peptide bonds, so the primary structure is preserved.
Ref: Lippincott's Illustrated Reviews Biochemistry, 5e, Structure of Proteins, p 13.
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