Question:
Which of the following is released during conversion of succinate to fumarate in TCA cycle?
Which of the following is released during conversion of succinate to fumarate in TCA cycle?
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TCA cycle FAD-dependent step:
- Succinate dehydrogenase: Succinate $\rightarrow$ Fumarate + FADH2.
- FADH2 enters the electron transport chain at Complex II.
- Succinate dehydrogenase: Succinate $\rightarrow$ Fumarate + FADH2.
- FADH2 enters the electron transport chain at Complex II.
Updated On: Aug 27, 2026
- CO2
- FADH2
- H2O
- ATP
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Understanding the Question:
This question tests knowledge of the TCA (Krebs) cycle and its intermediates.
Step 2: Detailed Explanation:
The conversion of succinate to fumarate is catalyzed by succinate dehydrogenase.
This is the only TCA cycle enzyme that uses FAD as a cofactor.
During this reaction, FAD is reduced to FADH2.
CO2 (A) is released during decarboxylation steps (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase).
H2O (C) is not released in this step.
ATP (D) is produced by substrate-level phosphorylation in the TCA cycle (succinyl-CoA synthetase).
Thus, the correct answer is FADH2.
Step 3: Final Answer:
Thus, FADH2 is released during the conversion of succinate to fumarate, which corresponds to option (B).
[0.5cm]
This question tests knowledge of the TCA (Krebs) cycle and its intermediates.
Step 2: Detailed Explanation:
The conversion of succinate to fumarate is catalyzed by succinate dehydrogenase.
This is the only TCA cycle enzyme that uses FAD as a cofactor.
During this reaction, FAD is reduced to FADH2.
CO2 (A) is released during decarboxylation steps (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase).
H2O (C) is not released in this step.
ATP (D) is produced by substrate-level phosphorylation in the TCA cycle (succinyl-CoA synthetase).
Thus, the correct answer is FADH2.
Step 3: Final Answer:
Thus, FADH2 is released during the conversion of succinate to fumarate, which corresponds to option (B).
[0.5cm]
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