Question:
Which of the following is NOT a Class 1C anti-arrhythmic drug:
Which of the following is NOT a Class 1C anti-arrhythmic drug:
Updated On: Jul 14, 2026
- Propafenone
- Mexiletine
- Flecainide
- Moricizine
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The Correct Option is B
Approach Solution - 1
The correct option is (B): Mexiletine
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The question asks which drug listed is NOT a Class 1C anti-arrhythmic. Let's classify each drug according to the Vaughan Williams classification.
- Propafenone: This drug is a well known Class 1C anti-arrhythmic. It strongly blocks fast sodium channels and slows conduction significantly, which is characteristic of the 1C subclass.
- Mexiletine: This drug is a Class 1B anti-arrhythmic, related to lidocaine. Class 1B drugs bind and dissociate from sodium channels quickly and have a comparatively weak effect on conduction velocity, which sets them apart from the 1C subclass. This makes it the drug that does NOT belong to Class 1C.
- Flecainide: This is a classic Class 1C anti-arrhythmic, known for its potent and long-lasting sodium channel blockade and marked slowing of cardiac conduction.
- Moricizine: This drug has properties spanning multiple subclasses but is generally grouped with Class 1C agents because of its strong sodium channel blocking effect and slow dissociation kinetics.
Propafenone, flecainide and moricizine all share the strong, slow-dissociating sodium channel block that defines Class 1C, while mexiletine's fast dissociation kinetics place it in Class 1B instead.
Therefore, the correct answer is Mexiletine.
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