Question:
Which of the following is not a basic amino acid?
Which of the following is not a basic amino acid?
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Basic amino acids: Lysine (Lys), Arginine (Arg), Histidine (His).
Leucine (Leu) is a neutral, nonpolar amino acid.
Updated On: Apr 16, 2026
- Leucine
- Lysine
- Arginine
- Histidine
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The Correct Option is A
Solution and Explanation
Concept:
Amino acids are classified based on the nature of their side chain (R-group). Basic amino acids have an additional amino group (\(-NH_2\)) or nitrogen-containing group in their side chain that can accept a proton, making them positively charged at physiological pH.
Step 1: Identify basic amino acids. The three standard basic amino acids are:
• Lysine — contains an extra \(\varepsilon\)-amino group (\(-(CH_2)_4NH_2\))
• Arginine — contains a guanidino group (\(-NH-C(NH)NH_2\))
• Histidine — contains an imidazole ring (can accept a proton) All three are positively charged at physiological pH.
Step 2: Check Leucine. Leucine has a nonpolar, aliphatic side chain (\(-CH_2CH(CH_3)_2\)). It contains no additional amino or basic group. It is a neutral (nonpolar) amino acid.
Step 3: Conclusion. Since Leucine lacks a basic side chain and is not positively charged at physiological pH, it is not a basic amino acid.
Step 1: Identify basic amino acids. The three standard basic amino acids are:
• Lysine — contains an extra \(\varepsilon\)-amino group (\(-(CH_2)_4NH_2\))
• Arginine — contains a guanidino group (\(-NH-C(NH)NH_2\))
• Histidine — contains an imidazole ring (can accept a proton) All three are positively charged at physiological pH.
Step 2: Check Leucine. Leucine has a nonpolar, aliphatic side chain (\(-CH_2CH(CH_3)_2\)). It contains no additional amino or basic group. It is a neutral (nonpolar) amino acid.
Step 3: Conclusion. Since Leucine lacks a basic side chain and is not positively charged at physiological pH, it is not a basic amino acid.
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