Which of the following is a Partial Fatty acid oxidation (pFox) inhibitor:
Show Hint
- \( \text{Trimetazidine} \)
- \( \text{Atosiban} \)
- \( \text{Verapamil} \)
- \( \text{Nicardipine} \)
The Correct Option is A
Solution and Explanation
Step 1: Understanding pFox inhibitors. Partial Fatty acid oxidation (pFox) inhibitors, such as Trimetazidine, work by shifting myocardial energy metabolism from fatty acid oxidation to glucose oxidation. This is more oxygen-efficient and helps improve cardiac efficiency, especially in conditions like ischemic heart disease.
Step 2: Explanation of Trimetazidine. Trimetazidine is the prototype pFox inhibitor. It selectively inhibits long-chain 3-ketoacyl-CoA thiolase (an enzyme involved in fatty acid oxidation), thereby enhancing glucose oxidation and reducing myocardial oxygen demand.
Step 3: Comparison with other options. - Option \( (B) \): Atosiban is an oxytocin receptor antagonist used in preterm labor, not a pFox inhibitor.
- Option \( (C) \): Verapamil is a calcium channel blocker used for angina and arrhythmias, not a pFox inhibitor.
- Option \( (D) \): Nicardipine is also a calcium channel blocker and not related to fatty acid oxidation.
Conclusion: Trimetazidine is the correct answer as a pFox inhibitor.
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