Which of the following hypersensitivity reactions involves the complement activation?
Show Hint
- Both Type I and Type III hypersensitivity
- Only Type I hypersensitivity
- Both Type I and Type II hypersensitivity
- Both Type II and Type III hypersensitivity
The Correct Option is D
Solution and Explanation
Step 1: Concept
Hypersensitivity reactions are categorized by the mechanisms used to damage tissue.
Step 2: Meaning
Complement activation leads to inflammation and cell lysis.
Step 3: Analysis
Type I is IgE-mediated (mast cell degranulation) and does not involve complement. Type II involves IgG/IgM binding to cell-surface antigens, which activates complement to kill the cell. Type III involves immune complexes that deposit in tissues and activate complement, causing local inflammation.
Step 4: Conclusion
Complement is a hallmark of the pathological damage seen in Types II and III. Final Answer: (D)
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