Question

Which of the following drug is having a 1,3,4-thiadiazole ring system:

• A. Dichlorophenamide
• B. Spironolactone
• C. Acetazolamide
• D. Furosemide

Answer 1

The Correct Option is C

The correct option is (C): Acetazolamide.

Answer 2

The question asks which of the four drugs carries a 1,3,4-thiadiazole ring in its structure. Let's check each one.

1. Dichlorophenamide: This drug is built on a benzene ring carrying two sulfonamide groups and two chlorine atoms. It has no thiadiazole ring anywhere in its structure.
2. Spironolactone: Spironolactone is a steroid-based aldosterone antagonist, built on the standard steroid nucleus with a lactone ring. It contains no thiadiazole ring.
3. Acetazolamide: Acetazolamide is built around a 1,3,4-thiadiazole ring carrying a sulfonamide group and an acetamido group. This ring system is exactly what gives the drug its carbonic anhydrase inhibiting activity.
4. Furosemide: Furosemide is an anthranilic acid derivative carrying a furan ring and a sulfonamide group. The furan ring should not be confused with a thiadiazole ring; the two are chemically different heterocycles.

Of the four, only acetazolamide is built on the 1,3,4-thiadiazole scaffold.

So the correct answer is Acetazolamide.