Question:
Which of the following compounds/intermediates of Krebs cycle do NOT undergo either decarboxylation or oxidation?
Which of the following compounds/intermediates of Krebs cycle do NOT undergo either decarboxylation or oxidation?
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Fumarate is converted to malate by hydration via fumarase enzyme.
Updated On: Mar 6, 2026
- Isocitric acid
- $\alpha$-ketoglutaric acid
- Fumaric acid
- Malic acid
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The Correct Option is C
Solution and Explanation
Step 1: Understanding Krebs cycle reactions.
The Krebs cycle involves a series of oxidation and decarboxylation reactions to release energy.
Step 2: Analyzing each intermediate.
Isocitric acid and $\alpha$-ketoglutaric acid undergo oxidative decarboxylation.
Malic acid undergoes oxidation to form oxaloacetic acid.
Fumaric acid undergoes hydration, not oxidation or decarboxylation.
Step 3: Conclusion.
Thus, fumaric acid does not undergo oxidation or decarboxylation in the Krebs cycle.
The Krebs cycle involves a series of oxidation and decarboxylation reactions to release energy.
Step 2: Analyzing each intermediate.
Isocitric acid and $\alpha$-ketoglutaric acid undergo oxidative decarboxylation.
Malic acid undergoes oxidation to form oxaloacetic acid.
Fumaric acid undergoes hydration, not oxidation or decarboxylation.
Step 3: Conclusion.
Thus, fumaric acid does not undergo oxidation or decarboxylation in the Krebs cycle.
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