Question:
Which of the following are non-ionic iodinated contrast agent(s)?
(A) Diatrizoate meglumine
(B) Iothalamate
(C) Iohexol
(D) Iopamidol
Choose the correct answer from the options given below:
Which of the following are non-ionic iodinated contrast agent(s)?
(A) Diatrizoate meglumine
(B) Iothalamate
(C) Iohexol
(D) Iopamidol
Choose the correct answer from the options given below:
(A) Diatrizoate meglumine
(B) Iothalamate
(C) Iohexol
(D) Iopamidol
Choose the correct answer from the options given below:
Show Hint
For myelography (imaging the spinal cord), only non-ionic water-soluble contrast agents (like Iohexol or Iopamidol) must be used.
Using ionic agents (like Diatrizoate) intrathecally is contraindicated because they cause severe muscle spasms, seizures, and death.
Using ionic agents (like Diatrizoate) intrathecally is contraindicated because they cause severe muscle spasms, seizures, and death.
Updated On: Jul 23, 2026
- (A) and (D) only.
- (A) and (B) only.
- (C) and (D) only.
- (B) and (D) only.
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
Iodinated water-soluble contrast media are classified into ionic and non-ionic compounds based on whether they dissociate into anions and cations in solution.
This chemical structure affects their osmolality and clinical safety profile, particularly for sensitive procedures like myelography.
Step 2: Detailed Explanation:
Let us analyze each of the contrast agents listed in the options:
- (A) Diatrizoate meglumine:
This is an ionic monomeric contrast agent.
In solution, it dissociates into a radiopaque anion containing the tri-iodinated benzene ring and a cation (meglumine).
It is highly hyperosmolar and can cause significant adverse reactions if used intrathecally.
- (B) Iothalamate:
This is another traditional, high-osmolar, ionic monomeric contrast agent that dissociates into ions in solution.
- (C) Iohexol:
This is a low-osmolar, non-ionic monomeric contrast agent.
It contains three iodine atoms bound to a benzene ring but does not dissociate into ions in solution.
Because it does not increase the ionic particle count, it has much lower osmolality and is highly safe for myelography (intrathecal injection).
- (D) Iopamidol:
Like iohexol, this is a low-osmolar, non-ionic monomeric contrast agent with an excellent safety and tolerability profile.
Thus, (C) Iohexol and (D) Iopamidol are non-ionic iodinated contrast agents.
Step 3: Final Answer:
The correct option is (C), representing (C) and (D) only.
Iodinated water-soluble contrast media are classified into ionic and non-ionic compounds based on whether they dissociate into anions and cations in solution.
This chemical structure affects their osmolality and clinical safety profile, particularly for sensitive procedures like myelography.
Step 2: Detailed Explanation:
Let us analyze each of the contrast agents listed in the options:
- (A) Diatrizoate meglumine:
This is an ionic monomeric contrast agent.
In solution, it dissociates into a radiopaque anion containing the tri-iodinated benzene ring and a cation (meglumine).
It is highly hyperosmolar and can cause significant adverse reactions if used intrathecally.
- (B) Iothalamate:
This is another traditional, high-osmolar, ionic monomeric contrast agent that dissociates into ions in solution.
- (C) Iohexol:
This is a low-osmolar, non-ionic monomeric contrast agent.
It contains three iodine atoms bound to a benzene ring but does not dissociate into ions in solution.
Because it does not increase the ionic particle count, it has much lower osmolality and is highly safe for myelography (intrathecal injection).
- (D) Iopamidol:
Like iohexol, this is a low-osmolar, non-ionic monomeric contrast agent with an excellent safety and tolerability profile.
Thus, (C) Iohexol and (D) Iopamidol are non-ionic iodinated contrast agents.
Step 3: Final Answer:
The correct option is (C), representing (C) and (D) only.
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