Question

Which NSAID undergoes enterohepatic circulation?

• A. . Piroxicam
• B. . Ibuprofen
• C. . Aspirin
• D. . Phenylbutaxone

Hint:

Remember that enterohepatic circulation can significantly extend a drug's half-life and duration of action. For NSAIDs, ibuprofen is a key example of a drug that utilizes this pathway.

Answer 1

The Correct Option is B

Step 1: Understanding the Question:
The question asks to identify which of the listed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) undergoes enterohepatic circulation.

Step 3: Detailed Explanation:
* Enterohepatic circulation: This is the recirculation of substances (like drugs, bile acids) from the liver to the bile, then to the small intestine, and finally back to the liver via the portal vein. This process can prolong the half-life of a drug.
* Ibuprofen: Ibuprofen is known to undergo enterohepatic circulation. After absorption, it is metabolized in the liver, primarily by glucuronidation. These glucuronide conjugates are then excreted into the bile, re-enter the intestine, and can be deconjugated by gut bacteria, releasing free ibuprofen, which is then reabsorbed, thus prolonging its presence in the body.
* Piroxicam: While it has a long half-life, enterohepatic recirculation is not its primary characteristic.
* Aspirin (acetylsalicylic acid): It is rapidly hydrolyzed to salicylic acid, which is then excreted. It does not undergo significant enterohepatic circulation in its active form.
* Phenylbutazone: This is an older NSAID, known for serious side effects, and while it undergoes metabolism, enterohepatic circulation is not its defining pharmacokinetic feature in this context.
Therefore, Ibuprofen is the NSAID among the options that prominently undergoes enterohepatic circulation.

Step 4: Final Answer:
Ibuprofen undergoes enterohepatic circulation.