Question:
Which is not a feature of Down syndrome?
Which is not a feature of Down syndrome?
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Look for the sign that is not part of the trisomy 21 phenotype.
Updated On: Jun 24, 2026
- Clinodactyly
- Pigmented birth marks
- Hypotonia
- Respiratory tract infections
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The Correct Option is B
Solution and Explanation
Step 1: Recall the features of Down syndrome (trisomy 21). General features include mental retardation and short stature. Craniofacial features include brachycephaly, epicanthic folds, a protruding tongue, small ears, upward slanting palpebral fissures (Mongoloid slant), strabismus, nystagmus and Brushfield spots in the iris.
Step 2: Limb and other features. Limb features include fifth finger clinodactyly, a single palmar (simian) crease and a wide sandal gap between the first and second toes. Hypotonia (floppiness) is a classic neonatal sign, and recurrent respiratory tract infections are common because of immune and structural factors.
Step 3: Match the options. Clinodactyly (a), hypotonia (c) and respiratory tract infections (d) are all recognized features of Down syndrome.
Step 4: Identify the odd one out. Pigmented birth marks are not a characteristic feature of Down syndrome; they are not part of its typical phenotype. Hence option b is the feature that is NOT seen, making it the correct answer.
Step 2: Limb and other features. Limb features include fifth finger clinodactyly, a single palmar (simian) crease and a wide sandal gap between the first and second toes. Hypotonia (floppiness) is a classic neonatal sign, and recurrent respiratory tract infections are common because of immune and structural factors.
Step 3: Match the options. Clinodactyly (a), hypotonia (c) and respiratory tract infections (d) are all recognized features of Down syndrome.
Step 4: Identify the odd one out. Pigmented birth marks are not a characteristic feature of Down syndrome; they are not part of its typical phenotype. Hence option b is the feature that is NOT seen, making it the correct answer.
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