Question:
Which enzymes are released from cytotoxic T-lymphocytes that help in apoptosis?
Which enzymes are released from cytotoxic T-lymphocytes that help in apoptosis?
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Perforins open pores; granzymes enter and trigger apoptosis.
Updated On: Jun 19, 2026
- Lysosome
- Granzymes
- Nuclease
- Perforins
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The Correct Option is B
Solution and Explanation
Step 1: Understand cytotoxic T-cells.
Cytotoxic T lymphocytes (CTLs) destroy infected or abnormal cells using specialized proteins.
Step 2: Role of perforins.
Perforins create pores in the target cell membrane to allow entry of cytotoxic molecules.
Step 3: Role of granzymes.
Granzymes are serine protease enzymes that enter target cells and trigger apoptosis.
Step 4: Mechanism of apoptosis.
Granzymes activate caspases which initiate programmed cell death.
Step 5: Eliminate incorrect options.
Lysosomes are cellular organelles, not CTL secreted enzymes; nucleases are general DNA-degrading enzymes.
Step 6: Conclusion.
Thus, granzymes are the correct enzymes responsible for apoptosis.
Cytotoxic T lymphocytes (CTLs) destroy infected or abnormal cells using specialized proteins.
Step 2: Role of perforins.
Perforins create pores in the target cell membrane to allow entry of cytotoxic molecules.
Step 3: Role of granzymes.
Granzymes are serine protease enzymes that enter target cells and trigger apoptosis.
Step 4: Mechanism of apoptosis.
Granzymes activate caspases which initiate programmed cell death.
Step 5: Eliminate incorrect options.
Lysosomes are cellular organelles, not CTL secreted enzymes; nucleases are general DNA-degrading enzymes.
Step 6: Conclusion.
Thus, granzymes are the correct enzymes responsible for apoptosis.
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