Question

Which database serves as the main archive for 3D macromolecular structures?

• A. GenBank
• B. Protein Data Bank (PDB)
• C. UniProt
• D. EMBL

Hint:

3D structures of proteins, DNA, and RNA → stored in {Protein Data Bank (PDB)}

Answer 1

The Correct Option is B

Concept:
Structural biology focuses on determining the three-dimensional structures of biological macromolecules such as proteins, DNA, and RNA. These structures are essential for understanding molecular function and interactions.
Step 1:Understanding structural databases.
Specialized databases store experimentally determined 3D structures of biological molecules.
Step 2:Protein Data Bank (PDB).
The Protein Data Bank (PDB) is the primary global archive that stores three-dimensional structures of biological macromolecules determined using techniques such as:

• X-ray crystallography
• Nuclear Magnetic Resonance (NMR) spectroscopy
• Cryo-electron microscopy (Cryo-EM)

Step 3:Importance of PDB.
Researchers use PDB data for:

• Drug design
• Protein structure prediction
• Studying molecular interactions
• Structural bioinformatics research

Conclusion:
Therefore, the main archive for 3D macromolecular structures is the Protein Data Bank (PDB).