Question:
Which among the following is an amino-alcohol analogue that has weak visceral anticholinerergic activity but is a strong nicotinolytic drug?
Which among the following is an amino-alcohol analogue that has weak visceral anticholinerergic activity but is a strong nicotinolytic drug?
Updated On: Feb 24, 2026
- Biperiden
- Orphenadrine
- Poldine
- Propantheline
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The Correct Option is A
Solution and Explanation
The question asks us to identify which of the given drugs is an amino-alcohol analogue with specific pharmacological characteristics: weak visceral anticholinergic activity but strong nicotinolytic action.
- Biperiden: Biperiden is known as an amino-alcohol ether with anticholinergic properties. It is primarily used in the treatment of Parkinson's disease. It is characterized by having both anticholinergic and nicotinolytic effects due to its structural analogies with both types of neurotransmitter activities.
- Orphenadrine: Orphenadrine is another amino-alcohol used as a muscle relaxant. It has anticholinergic properties but is not specifically characterized by strong nicotinolytic action, making it less relevant to the strong nicotinolytic activity mentioned.
- Poldine: Poldine is a quaternary ammonium compound with anticholinergic activity. It does not possess the strong nicotinolytic properties specified in the question.
- Propantheline: Propantheline is used for its antispasmodic and anticholinergic properties but is not known for strong nicotinolytic effects, which makes it unlikely to be the correct answer.
Based on the known properties of these compounds, Biperiden fits the description given in the question best, as it is an amino-alcohol analogue with both weak visceral anticholinergic and strong nicotinolytic activities. Hence, the correct answer is Biperiden.
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