Concept:
The Gutenberg Bible is one of the earliest major books printed in Europe using movable metal type.
It was printed by Johannes Gutenberg and marks an important stage in the history of printing.
Step 1: Understand the importance of Gutenberg Bible.
Before printing technology, books were copied by hand.
This process was slow, expensive, and time-consuming.
The invention of movable type printing made the production of books faster and cheaper.
Step 2: Identify the period of Gutenberg Bible.
The Gutenberg Bible was printed in the middle of the fifteenth century.
It is generally associated with the year around:
\[
1455 \text{--} 1456 \ CE
\]
Among the given options, the correct year is:
\[
1456 \ CE
\]
Step 3: Final conclusion.
Hence, the first Gutenberg Bible was printed in:
\[
\boxed{1456 \ CE}
\]