Concept:
An auto transformer uses a single winding which is common to both primary and secondary circuits.
Step 1: In a two-winding transformer, primary and secondary windings are electrically isolated from each other.
Step 2: But in an auto transformer, a part of the winding is common to both sides.
Step 3: Because of this common winding, there is no complete electrical isolation between input and output.
Step 4: This can be dangerous in fault conditions because high voltage may be transferred to the low-voltage side.
Therefore, the major disadvantage is:
\[
\boxed{\text{Lack of electrical isolation between primary and secondary}}
\]