Question:
What is the best time to perform the quadruple (quad) test?
What is the best time to perform the quadruple (quad) test?
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It is a second-trimester serum screen.
Updated On: Jun 24, 2026
- 8-12 weeks
- 11-15 weeks
- 15-20 weeks
- 18-22 weeks
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: The quadruple test is a second-trimester maternal serum screen measuring AFP, hCG, unconjugated estriol and inhibin A to assess risk of aneuploidy and neural tube defects.
Step 2: It is performed in the second trimester, most reliably between 15 and 20 weeks of gestation, so option C is correct.
Step 3: The 8 to 12 week and 11 to 15 week windows correspond to first-trimester screening, and 18 to 22 weeks is later than the optimal interval, making them less appropriate.
Step 2: It is performed in the second trimester, most reliably between 15 and 20 weeks of gestation, so option C is correct.
Step 3: The 8 to 12 week and 11 to 15 week windows correspond to first-trimester screening, and 18 to 22 weeks is later than the optimal interval, making them less appropriate.
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