Question:
What is the best time during pregnancy to perform the quadruple (quad) test?
What is the best time during pregnancy to perform the quadruple (quad) test?
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Quad test is a second-trimester screen, done at 15-20 weeks.
Updated On: Jun 23, 2026
- 8-12 weeks
- 11-15 weeks
- 15-20 weeks
- 18-22 weeks
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: The quadruple (quad) test is a second-trimester maternal serum screening test for aneuploidies and neural tube defects. Step 2: It measures four analytes: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3), and inhibin A. Step 3: The optimal window to draw the quad test is the second trimester, usually between 15 and 20 weeks of gestation, which corresponds to option c. Step 4: The earlier windows in options a, b, and the start of d correspond to first-trimester or combined-screening timing (such as the dual test or nuchal translucency at 11 to 14 weeks), not the quad test, so 15 to 20 weeks is correct.
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