Question:
The oxyhaemoglobin dissociation curve shifts towards left due to increase in ___________.
The oxyhaemoglobin dissociation curve shifts towards left due to increase in ___________.
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A left shift means higher oxygen affinity of haemoglobin, which occurs with higher pH, lower temperature, lower DPG and lower carbon dioxide.
Updated On: Nov 12, 2026
- pH
- temperature
- DPG
- \(\text{ppCO}_{2}\)
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept
The oxyhaemoglobin dissociation curve shifts to the left when haemoglobin binds oxygen more tightly (higher affinity).
Step 2: Factors causing a left shift
Low \(\text{H}^{+}\) concentration (increase in pH), low temperature, low \(\text{ppCO}_{2}\) and low DPG cause a left shift.
Step 3: Compare the options
Increase in temperature, DPG or \(\text{ppCO}_{2}\) lowers affinity and shifts the curve to the right. Only an increase in pH shifts it to the left.
Final Answer:
An increase in pH shifts the curve to the left. \[ \boxed{\text{(A) }\text{pH}} \]
The oxyhaemoglobin dissociation curve shifts to the left when haemoglobin binds oxygen more tightly (higher affinity).
Step 2: Factors causing a left shift
Low \(\text{H}^{+}\) concentration (increase in pH), low temperature, low \(\text{ppCO}_{2}\) and low DPG cause a left shift.
Step 3: Compare the options
Increase in temperature, DPG or \(\text{ppCO}_{2}\) lowers affinity and shifts the curve to the right. Only an increase in pH shifts it to the left.
Final Answer:
An increase in pH shifts the curve to the left. \[ \boxed{\text{(A) }\text{pH}} \]
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