Step 1: Understand the rate of growth.
We are told that the micro-organisms double in 3 hours, and the growth is proportional to the current number of organisms. This suggests exponential growth, and we can use the exponential growth formula:
\[
N(t) = N_0 e^{kt}
\]
where \( N_0 \) is the initial quantity, \( k \) is the rate constant, and \( t \) is the time.
Step 2: Determine the number of times the quantity doubles.
The problem asks how many times the quantity doubles in 18 years. First, we convert 18 years into hours:
\[
18 \, \text{years} = 18 \times 365 \times 24 \, \text{hours}.
\]
Using this information, we calculate the total number of doublings.
Step 3: Conclusion.
The number of times the micro-organisms multiply in 18 years is 64, corresponding to option (B).