Step 1: Understanding the Concept
Enamel covers the crown of a tooth and is about 96 to 97 percent mineral (hydroxyapatite crystals of calcium phosphate), secreted by ameloblasts.
Step 2: Compare
Dentin, beneath it, and cementum, covering the root, contain much more organic matter and are softer.
Step 3: Other option
Histone is a chromosomal protein, not a hard tissue.
Final Answer:
Enamel is the hardest substance of the human body.
\[ \boxed{\text{(A) }\text{enamel}} \]