Step 1: Select two different vowels.
There are \(5\) vowels in the English alphabet.
The number of ways to choose \(2\) different vowels is
\[
{}^{5}C_{2}
=
\frac{5!}{2!\,3!}
=
10
\]
Step 2: Select two different consonants.
There are \(21\) consonants in the English alphabet.
The number of ways to choose \(2\) different consonants is
\[
{}^{21}C_{2}
=
\frac{21!}{2!\,19!}
=
210
\]
Step 3: Form a four-letter word using the selected letters.
After choosing the letters, we have
\[
2 \text{ vowels } + 2 \text{ consonants }
\]
that is, a total of \(4\) distinct letters.
These \(4\) letters can be arranged in
\[
4!
\]
different ways.
Step 4: Apply the multiplication principle.
Therefore, the total number of required words is
\[
{}^{5}C_{2}
\times
{}^{21}C_{2}
\times
4!
\]
\[
=
10 \times 210 \times 4!
\]
\[
=
2100 \times 4!
\]
Step 5: Final conclusion.
Hence, the number of words that can be formed is
\[
\boxed{2100 \times 4!}
\]
Thus, the correct option is
\[
\boxed{(4)\ 2100 \times 4!}
\]