Step 1: Recall what treats malaria.
Malaria is caused by Plasmodium parasites carried by the Anopheles mosquito, and treating it needs drugs that specifically kill the parasite inside red blood cells.
Step 2: Identify chloroquine.
Chloroquine is a well known anti-malarial drug that works by building up inside the parasite and blocking its ability to safely handle a toxic byproduct it makes while feeding on haemoglobin. This blockage kills the parasite. Chloroquine has been used for decades as a standard treatment and prevention drug for malaria in many parts of the world.
Step 3: Rule out the other options.
Aspirin is a pain relieving and fever reducing drug, not an anti-malarial one.
Neoprene is a synthetic rubber used to make products like wetsuits and gaskets, with no role in medicine against malaria.
Isoprene is a small organic compound that is the basic building block of natural rubber and is unrelated to malaria treatment.
Step 4: Final conclusion.
The compound actually used as an anti-malarial drug among these four options is chloroquine.
\[ \boxed{\text{Chloroquine}} \]