Concept:
General term of binomial expansion:
\[
T_{k+1} = \binom{n}{k} a^{n-k} b^k
\]
Step 1: Identify components
\[
a = x^2, b = -\frac{2}{x}, n=6
\]
Step 2: General term
\[
T_{k+1} = \binom{6}{k} (x^2)^{6-k} \left(-\frac{2}{x}\right)^k
\]
Step 3: Simplify powers
\[
(x^2)^{6-k} = x^{12-2k}, \left(-\frac{2}{x}\right)^k = (-2)^k x^{-k}
\]
\[
T_{k+1} = \binom{6}{k} (-2)^k x^{12-3k}
\]
Step 4: Find required power
\[
12 - 3k = 3 \Rightarrow k=3
\]
Step 5: Coefficient
\[
\binom{6}{3}(-2)^3 = 20 \times (-8) = -160
\]
\[
\boxed{-160}
\]