Question:
The broad-spectrum systemic herbicide Glyphosate is formed by oxidative coupling of the methylphosphonic acid with amino group of which one of the following amino acids?
The broad-spectrum systemic herbicide Glyphosate is formed by oxidative coupling of the methylphosphonic acid with amino group of which one of the following amino acids?
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The name says it all: Glyphosate $\rightarrow$ Glycine.
It is the most successful herbicide in history, particularly when paired with Roundup Ready (GM) crops.
It is the most successful herbicide in history, particularly when paired with Roundup Ready (GM) crops.
Updated On: Aug 21, 2026
- Glycine
- Serine
- Cysteine
- Tyrosine
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Question:
Glyphosate is the active ingredient in Roundup. The question asks for the specific amino acid that forms the structural backbone of this herbicide.
Step 2: Detailed Explanation:
• Chemical Name of Glyphosate: Its technical IUPAC name is N-(phosphonomethyl)glycine.
• Structural Components: As the name implies, the molecule consists of a Glycine residue where the nitrogen atom is bonded to a phosphonomethyl group ($-CH_2-PO_3H_2$).
• Mode of Action: Glyphosate kills plants by acting as a competitive inhibitor of the enzyme EPSPS (5-enolpyruvylshikimate-3-phosphate synthase). This enzyme is essential for the Shikimate pathway.
• Metabolic Impact: By blocking EPSPS, glyphosate prevents the plant from synthesizing essential aromatic amino acids (Phenylalanine, Tyrosine, and Tryptophan), leading to the death of the plant.
• Synthesis: Commercially, it is produced by reacting methylphosphonic acid derivatives with the amino group of the simple amino acid Glycine.
Step 3: Final Answer:
The amino acid backbone of the herbicide Glyphosate is Glycine.
Glyphosate is the active ingredient in Roundup. The question asks for the specific amino acid that forms the structural backbone of this herbicide.
Step 2: Detailed Explanation:
• Chemical Name of Glyphosate: Its technical IUPAC name is N-(phosphonomethyl)glycine.
• Structural Components: As the name implies, the molecule consists of a Glycine residue where the nitrogen atom is bonded to a phosphonomethyl group ($-CH_2-PO_3H_2$).
• Mode of Action: Glyphosate kills plants by acting as a competitive inhibitor of the enzyme EPSPS (5-enolpyruvylshikimate-3-phosphate synthase). This enzyme is essential for the Shikimate pathway.
• Metabolic Impact: By blocking EPSPS, glyphosate prevents the plant from synthesizing essential aromatic amino acids (Phenylalanine, Tyrosine, and Tryptophan), leading to the death of the plant.
• Synthesis: Commercially, it is produced by reacting methylphosphonic acid derivatives with the amino group of the simple amino acid Glycine.
Step 3: Final Answer:
The amino acid backbone of the herbicide Glyphosate is Glycine.
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