Step 1: Understanding the Concept
\(y=\sqrt{16-x^2}\) is the upper half of the circle \(x^2+y^2=16\) of radius 4. The lines \(x=0\) and \(x=4\) cut out the first quadrant part.
Step 2: Area by integration
\[ A=\int_0^4\sqrt{16-x^2}\,dx=\left[\frac x2\sqrt{16-x^2}+8\sin^{-1}\frac x4\right]_0^4 \]
\[ =0+8\cdot\frac\pi2-0=4\pi \]
Step 3: Check by geometry
The area of the full circle is \(\pi r^2=16\pi\). One quarter is \(4\pi\). Both methods agree, so the answer is option (D). The options \(16\pi\), \(12\pi\) and \(8\pi\) correspond to the whole circle, three quarters and a half.
Final Answer:
The region is a quarter of a circle of radius 4, so its area is 4 pi, option (D).
\[ \boxed{4\pi} \]