Step 1: Concept
Ionization enthalpy decreases down a group in the periodic table.
Step 2: Meaning
Down the group, atomic size increases and shielding effect increases.
Step 3: Analysis
Lithium ($Li$) is at the top of the alkali metal group.
Step 4: Conclusion
Being the smallest atom, $Li$ has the highest ionization enthalpy.
Final Answer: (E)