Question:
Success of hepatitis B vaccine is because
Success of hepatitis B vaccine is because
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Recombinant Subunit Vaccines: Hepatitis B vaccine uses purified recombinant HBsAg (First commercial recombinant human vaccine, 1986). High safety and zero live reversion risk.
Updated On: Sep 4, 2026
- Sub unit vaccine made only with the essential antigens ensures adverse reaction chances are minimized.
- Recombinant DNA technology usage ensures all epitope are covered.
- Entire microbe is used to create vaccine and immune system is stimulated by polyvalent source.
- Most of the molecules making the microorganisms are utilized after virulent region of pathogen is removed from the microbe.
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Recombinant protein subunit vaccines express only immunoprotective surface envelope proteins, eliminating live pathogen reversion and reactogenicity risks.
Step 2: Detailed Explanation:
Recombinant Hepatitis B Subunit Vaccine:
- The recombinant vaccine consists solely of the non-infectious Hepatitis B Surface Antigen (HBsAg) cloned and expressed as virus-like particles (VLPs) in baker's yeast (Saccharomyces cerevisiae) or CHO cells.
- Because the vaccine contains only the purified protective surface subunit antigen and completely lacks viral DNA, core antigens, or intact replication-competent virus, it induces robust neutralizing anti-HBs antibodies while eliminating live virus transmission risks and minimizing adverse hypersensitivity/toxic side effects.
Step 3: Final Answer:
Hence, its success is because Sub unit vaccine made only with the essential antigens ensures adverse reaction chances are minimized, matching option (A).
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