Step 1: Understand muscle activity.
During repeated or continuous skeletal muscle contraction, oxygen demand increases significantly.
Step 2: Oxygen limitation condition.
When oxygen supply becomes insufficient, muscles shift partially to anaerobic respiration for energy production.
Step 3: Role of anaerobic respiration.
In anaerobic conditions, glucose is broken down into lactic acid as the end product in muscle cells.
Step 4: Lactic acid accumulation.
Continuous muscle activity leads to accumulation of lactic acid in muscles, causing fatigue and pain.
Step 5: Analyze other options.
Calcium ions are involved in contraction but not accumulated due to repeated activation. Glucose synthesis and recovery occur later, not during continuous activation.
Step 6: Conclusion.
Therefore, repeated activation of skeletal muscles leads to accumulation of lactic acid.