Question:

Repeated activation of skeletal muscle leads to:

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Muscle fatigue during heavy exercise is mainly due to lactic acid buildup under anaerobic conditions.
Updated On: Jun 19, 2026
  • Accumulation of lactic acid
  • Release of calcium ions
  • Glucose synthesis
  • Recovery from fatigue
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The Correct Option is A

Solution and Explanation

Step 1: Understand muscle activity.
During repeated or continuous skeletal muscle contraction, oxygen demand increases significantly.

Step 2: Oxygen limitation condition.

When oxygen supply becomes insufficient, muscles shift partially to anaerobic respiration for energy production.

Step 3: Role of anaerobic respiration.

In anaerobic conditions, glucose is broken down into lactic acid as the end product in muscle cells.

Step 4: Lactic acid accumulation.

Continuous muscle activity leads to accumulation of lactic acid in muscles, causing fatigue and pain.

Step 5: Analyze other options.

Calcium ions are involved in contraction but not accumulated due to repeated activation. Glucose synthesis and recovery occur later, not during continuous activation.

Step 6: Conclusion.

Therefore, repeated activation of skeletal muscles leads to accumulation of lactic acid.
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