Question

Progression of the disease leads to degeneration of neurons and presence of cytoplasmic inclusion bodies, called Lewy bodies. This is seen in which disease of the nervous system?

• A. Amyotrophic lateral sclerosis
• B. Cauda Equina syndrome
• C. Parkinson's Disease
• D. Syringomyelia

Hint:

Lewy bodies → Parkinson’s disease Think: Alpha-synuclein accumulation = PD

Answer 1

The Correct Option is C

Concept:
Neurodegenerative diseases are characterized by progressive loss of structure and function of neurons. One of the hallmark pathological features in certain disorders is the presence of abnormal protein aggregates. Lewy bodies are:
• Intracytoplasmic inclusion bodies
• Composed mainly of alpha-synuclein protein
• Found in degenerating neurons

Step 1: Understanding the pathology mentioned.
The question specifies:
• Degeneration of neurons
• Presence of Lewy bodies This combination is highly characteristic of a specific neurodegenerative disease.

Step 2: Identifying the disease associated with Lewy bodies.
Lewy bodies are classically seen in:
• Parkinson's Disease
• Dementia with Lewy bodies

Step 3: Evaluating the options.

• Amyotrophic lateral sclerosis → involves motor neuron degeneration but no Lewy bodies
• Cauda equina syndrome → nerve root compression, not degenerative inclusion bodies
• Parkinson's disease → presence of Lewy bodies (correct)
• Syringomyelia → cyst formation in spinal cord

Step 4: Additional explanation.
In Parkinson’s disease:
• Degeneration occurs in substantia nigra
• Leads to decreased dopamine
• Causes symptoms like tremor, rigidity, bradykinesia

Step 5: Conclusion.
Thus, the disease described is: \[ \boxed{\text{Parkinson's Disease}} \]