Question:
MRP2 (multidrug resistance protein 2) is associated with which of the following conditions?
MRP2 (multidrug resistance protein 2) is associated with which of the following conditions?
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MRP2 equals ABCC2 equals cMOAT, the canalicular conjugated-bilirubin exporter.
Updated On: Jun 23, 2026
- Rotor syndrome
- Dubin-Johnson syndrome
- Crigler-Najjar syndrome
- Gilbert syndrome
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: The question links the canalicular transporter protein MRP2 to a specific inherited hyperbilirubinemia. MRP2 is also called the canalicular multispecific organic anion transporter (cMOAT) or ABCC2, and it pumps conjugated bilirubin from the hepatocyte into bile.
Step 2: Dubin-Johnson syndrome is an autosomal recessive disorder caused by a mutation in the gene that codes for this MRP2/ABCC2 protein. Loss of the transporter blocks excretion of conjugated bilirubin, producing a conjugated (direct) hyperbilirubinemia with a characteristic black pigmented liver.
Step 3: The distractors point to different defects. Rotor syndrome is a defect of hepatic storage and uptake with a non-pigmented liver. Crigler-Najjar and Gilbert syndromes are defects of UGT1A1 (glucuronosyl transferase), so they cause unconjugated hyperbilirubinemia, not an MRP2 problem.
Step 4: Because only Dubin-Johnson syndrome is caused by an MRP2/ABCC2 mutation, option b is correct.
Step 2: Dubin-Johnson syndrome is an autosomal recessive disorder caused by a mutation in the gene that codes for this MRP2/ABCC2 protein. Loss of the transporter blocks excretion of conjugated bilirubin, producing a conjugated (direct) hyperbilirubinemia with a characteristic black pigmented liver.
Step 3: The distractors point to different defects. Rotor syndrome is a defect of hepatic storage and uptake with a non-pigmented liver. Crigler-Najjar and Gilbert syndromes are defects of UGT1A1 (glucuronosyl transferase), so they cause unconjugated hyperbilirubinemia, not an MRP2 problem.
Step 4: Because only Dubin-Johnson syndrome is caused by an MRP2/ABCC2 mutation, option b is correct.
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