Question

Match the following concept in List I with parameters in List II:

	List I Concept		List II Parameters
A	Volume of distribution	I	Measure volume of real physiological plasma
B	Evans blue	II	Human serum albumin
C	3.5-5%	III	Volume of blood
D	Metallothionin	IV	Ratioofbodydrug content to plasma concentration
	-	V	Protein present in kidney to bind metal

Choose the correct answer from the options give below:

• A. A-I, B-II, C-III, D-IV
• B. A-I, B-IV, C-III, D-II
• C. A-IV, B-I, C-II, D-V
• D. A-III, B-II, C-IV, D-V

Answer 1

The Correct Option is C

To solve this question, we need to match each item in List I to the correct parameter in List II based on their relationships in pharmacology.

1. Volume of distribution (A): This term is often used in pharmacology to describe the volume in which a drug would need to be uniformly distributed to provide the same concentration as it is in blood plasma. This is described by the ratio of the total amount of drug in the body to the concentration of the drug in plasma. Hence, the correct match is with IV: Ratio of body drug content to plasma concentration. 
2. Evans blue (B): Evans blue is a dye used in the dye dilution method to estimate plasma volume as it binds strongly to plasma proteins, such as human serum albumin. Thus, it should be matched with I: Measure volume of real physiological plasma.
3. 3.5-5% (C): This range is typically associated with the normal concentration of proteins in the blood, specifically human serum albumin. Therefore, it corresponds to II: Human serum albumin.
4. Metallothionein (D): Metallothioneins are proteins that bind metals and are present in the kidney and liver. They help in metal detoxification and the regulation of zinc and copper ions. Therefore, it matches V: Protein present in kidney to bind metal.

Based on these matches, the correct answer is:

A	IV
B	I
C	II
D	V

Therefore, the correct option is A-IV, B-I, C-II, D-V.