Question

Match the following Class and their Drug:
(1) Alkylating                       (P) 5-fluorouracil
(2) Platinum analog             (Q) Cisplatin
(3) Antimetabolite               (R) Cetuximab
(4) EGF receptor inhibitor   (S) Chlorambucil

• A. (1)-(P), (2)-(S), (3)-(Q), (4)-(R)
• B. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)
• C. (1)-(S), (2)-(Q), (3)-(P), (4)-(R)
• D. (1)-(Q), (2)-(R), (3)-(P), (4)-(S)

Hint:

When matching drug classes, focus on their mechanism of action: alkylating agents modify DNA, platinum compounds crosslink DNA, antimetabolites interfere with nucleotide synthesis, and EGF inhibitors block receptor signaling.

Answer 1

The Correct Option is C

Alkylating agents such as Chlorambucil (S) work by adding alkyl groups to DNA, interfering with replication. Platinum analogs like Cisplatin (Q) form DNA crosslinks inhibiting DNA synthesis. Antimetabolites, such as 5-fluorouracil (P), inhibit nucleotide synthesis by mimicking natural metabolites. EGF receptor inhibitors, like Cetuximab (R), block epidermal growth factor receptor signaling to prevent cancer cell growth.

Hence, the correct matching is (1)-(S), (2)-(Q), (3)-(P), (4)-(R).