Question

Match List I with List II

List I (Genetic disorders)	List II (Type)
(A). Thalassemia	(I). X-monosomy
(B). Turner's syndrome	(II). Extra X-chromosome
(C). Klinefelter's syndrome	(III). 21\({}^{st}\) Trisomy
(D). Down's syndrome	(IV). Mendelian disorder

Choose the correct answer from the options given below:

• (A) - (IV), (B) - (I), (C) - (II), (D) - (III)
• (A) - (II), (B) - (IV), (C) - (I), (D) - (III)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Recall which disorders are Mendelian and which are chromosomal. Turner's is XO, Klinefelter's is XXY and Down's is trisomy 21.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept
Genetic disorders are either Mendelian (single gene defects) or chromosomal (change in chromosome number).

Step 2: Match each disorder
Thalassemia is a Mendelian disorder, so A matches IV.
Turner's syndrome (44 + XO) is X-monosomy, so B matches I.
Klinefelter's syndrome (44 + XXY) has an extra X chromosome, so C matches II.
Down's syndrome is trisomy of chromosome 21, so D matches III.

Step 3: Select the option
The combination A-IV, B-I, C-II, D-III is given in option A.

Final Answer:
The correct matching is A-IV, B-I, C-II, D-III. \[ \boxed{\text{(A) }\text{(A) - (IV), (B) - (I), (C) - (II), (D) - (III)}} \]