Question

Match List-I with List-II

List-I (Clotting Factors)	List-II (Synonym)
(A) Factor IX	(I) Hageman factor
(B) Factor X	(II) Stuart factor
(C) Factor XI	(III) Christmas factor
(D) Factor XII	(IV) Plasma thromboplastin antecedent

Choose the correct answer from the options given below

• (A) - (III), (B) - (II), (C) - (IV), (D) - (I)
• (A) - (II), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)
• (A) - (IV), (B) - (III), (C) - (I), (D) - (II)

Hint:

To remember key clotting factor synonyms:
- Factor IX = Christmas factor (leads to Hemophilia B).
- Factor XII = Hageman factor (initiates contact activation).
These two are frequently tested in veterinary physiology exams.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
The coagulation cascade is a physiological process involving a series of plasma proteins called clotting factors. Each factor is historically designated by a Roman numeral and has one or more common chemical or historical synonyms.

Step 2: Detailed Explanation:
Let us identify and pair each coagulation factor with its synonym:

A. Factor IX: This factor is widely known as theChristmas factor, named after Stephen Christmas, the first patient diagnosed with its deficiency (Hemophilia B). Thus, (A) matches with (III).

B. Factor X: This factor is known as theStuart factor (or Stuart-Prower factor), named after the patients in whom the deficiency was first identified. It represents the point where the intrinsic and extrinsic pathways converge into the common pathway. Thus, (B) matches with (II).

C. Factor XI: This factor is known asPlasma thromboplastin antecedent (PTA). A deficiency in this factor causes Hemophilia C. Thus, (C) matches with (IV).

D. Factor XII: This factor is known as theHageman factor. It is activated upon contact with negatively charged surfaces (like glass or collagen) to initiate the intrinsic pathway of blood clotting. Thus, (D) matches with (I).
Combining these matches, we obtain: (A) - (III), (B) - (II), (C) - (IV), (D) - (I).

Step 3: Final Answer:
The correct option is (A).