Question

Match List-I with List-II

List-I (Name of the lipid) & List-II (Nature of the lipid)
(A) Ceramide & (I) Ether glycerophospholipid
(B) Cerebroside & (IV) Neutral Glycosphingolipid
(C) Ganglioside & (II) Acidic (charged) glycosphingolipid
(D) Platelet Activating Factor & (III) Structural parent of all sphingolipids

• (A) - (II), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (II), (D) - (I)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Remember that Gangliosides always contain sialic acid, which makes them acidic and negatively charged. Platelet Activating Factor is a well-known example of an ether lipid, which distinguishes it from ester-linked glycerophospholipids.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Lipids are structurally diverse biomolecules classified into distinct groups based on their chemical backbones, including glycerophospholipids and sphingolipids.

Step 2: Detailed Explanation:
Let us analyze each pair to match the lipid names with their chemical characteristics:
- (A) Ceramide $\rightarrow$ (III) Structural parent of all sphingolipids:
A ceramide is formed by attaching a fatty acid to the amino group of a sphingosine backbone via an amide linkage.
It serves as the core hydrophobic structure from which all complex sphingolipids (sphingomyelins and glycosphingolipids) are synthesized.
- (B) Cerebroside $\rightarrow$ (IV) Neutral Glycosphingolipid:
Cerebrosides are glycosphingolipids containing a single uncharged monosaccharide unit (typically glucose or galactose) attached to the primary hydroxyl group of ceramide.
Since the sugar head group lacks a net electrical charge at physiological pH, it is classified as a neutral glycosphingolipid.
- (C) Ganglioside $\rightarrow$ (II) Acidic (charged) glycosphingolipid:
Gangliosides are complex glycosphingolipids containing an oligosaccharide head group with one or more sialic acid (N-acetylneuraminic acid) residues.
Sialic acid contains a carboxylate group that is ionized at physiological pH, rendering these lipids acidic and negatively charged.
- (D) Platelet Activating Factor $\rightarrow$ (I) Ether glycerophospholipid:
Platelet Activating Factor (PAF) is a potent biological mediator based on a glycerol backbone with an alkyl ether link at the C-1 position and an acetyl ester link at C-2, classifying it as an ether glycerophospholipid.
This results in the matching combination: (A)-(III), (B)-(IV), (C)-(II), (D)-(I).

Step 3: Final Answer:
The correct matching sequence is (A) - (III), (B) - (IV), (C) - (II), (D) - (I).