Question

Match List-I with List-II

List-I & List-II
(A). Semiconservative DNA replication & (I). Temin and Baltimore
(B). Reverse transcriptase & (II). Charpentier and Doudna
(C). Gene Editing & (III). Sanger
(D). Insulin & (IV). Watson and Crick

Choose the correct answer from the options given below:

• (A) - (V), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (IV), (B) - (I), (C) - (II), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Frederick Sanger was awarded two Nobel Prizes in Chemistry: his first in 1958 for sequencing insulin, and his second in 1980 for developing DNA sequencing methods.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
This matching question pairs fundamental discoveries in genetics and biochemistry with the scientists who made them.

Step 2: Detailed Explanation:
- (A) Semiconservative DNA replication matches with (IV) Watson and Crick: They proposed the double-helix structure in 1953 and suggested a semiconservative replication mechanism, which was later proven experimentally by Meselson and Stahl.
- (B) Reverse transcriptase matches with (I) Temin and Baltimore: They discovered reverse transcriptase in retroviruses in 1970, for which they were awarded the 1975 Nobel Prize.
- (C) Gene Editing matches with (II) Charpentier and Doudna: They developed the programmable CRISPR-Cas9 system for targeted gene editing.
- (D) Insulin matches with (III) Sanger: Frederick Sanger determined the complete amino acid sequence of insulin in 1955, establishing that proteins have defined chemical structures.
This sequence corresponds to Option 3.

Step 3: Final Answer:
The correct match is (A) - (IV), (B) - (I), (C) - (II), (D) - (III).