Question

Match List-I with List-II: 

List-I	List-II
(A) Dexmedetomidine	(I) Naloxone
(B) Diazepam	(II) Atipamizole
(C) d-Tubocurarine	(III) Neostigmine
(D) Fentanyl	(IV) Flumazenil

Choose the correct answer from the options given below:

• (A) - (IV), (B) - (II), (C) - (I), (D) - (III)
• (A) - (II), (B) - (IV), (C) - (III), (D) - (I)
• (A) - (IV), (B) - (I), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

To remember major anesthetic reversal pairs:
- Alpha-2 Agonists \(\rightarrow\) Atipamezole (Antisedan)
- Benzodiazepines \(\rightarrow\) Flumazenil
- Opioids \(\rightarrow\) Naloxone

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
In veterinary anesthesia, several drugs are paired with specific antagonists (reversal agents) that can bind to the same receptors and reverse their pharmacological effects.

Step 2: Detailed Explanation:
Let us match each drug with its specific reversal agent:
- (A) Dexmedetomidine: This is a potent, selective alpha-2 (\(\alpha_2\)) adrenergic agonist used for sedation.
Its effects can be reversed using atipamezole (II), a highly selective \(\alpha_2\)-receptor antagonist. Thus, (A) matches with (II).
- (B) Diazepam: This is a benzodiazepine derivative used as an anticonvulsant and sedative.
Its action can be reversed using flumazenil (IV), a competitive benzodiazepine receptor antagonist. Thus, (B) matches with (IV).
- (C) d-Tubocurarine: This is a non-depolarizing neuromuscular blocking agent that causes muscle paralysis by blocking nicotinic receptors.
It is reversed using acetylcholinesterase inhibitors like neostigmine (III), which increase acetylcholine levels at the neuromuscular junction to outcompete the blocker. Thus, (C) matches with (III).
- (D) Fentanyl: This is a potent synthetic opioid agonist.
Its respiratory depressant and sedative effects are reversed using naloxone (I), a competitive mu-opioid receptor antagonist. Thus, (D) matches with (I).
This matching sequence gives: (A) - (II), (B) - (IV), (C) - (III), (D) - (I).

Step 3: Final Answer:
The correct match is (A) - (II), (B) - (IV), (C) - (III), (D) - (I).