Question

Match List-I (Vitamins) with List-II (Deficiency Diseases): {ll} List - I & List - II
A. Vitamin B12 & I. Cheilosis
B. Vitamin D & II. Convulsions
C. Vitamin B2 & III. Rickets
D. Vitamin B6 & IV. Pernicious anaemia

• A. A-II, B-III, C-I, D-IV
• B. A-IV, B-III, C-II, D-I
• C. A-I, B-III, C-II, D-IV
• D. A-IV, B-III, C-I, D-II

Hint:

To eliminate options rapidly on exam questions, look for the most distinct and highly tested pairs. The link between Vitamin D and Rickets (\(\text{B} \rightarrow \text{III}\)) or Vitamin B12 and Pernicious anaemia (\(\text{A} \rightarrow \text{IV}\)) are classic textbook examples. Identifying either of these instantly narrows down your choices!

Answer 1

The Correct Option is D

Concept: Vitamins are essential micronutrients required by the human body in small quantities to perform specific biological functions. Since most vitamins cannot be synthesized internally by the body, an inadequate dietary intake leads to characteristic deficiency diseases:
• Vitamin B12 (Cyanocobalamin): Vital for red blood cell (RBC) maturation and neurological health.
• Vitamin D (Calciferol): Essential for the absorption of calcium and phosphorus, maintaining bone mineralization.
• Vitamin B2 (Riboflavin): Functions as a precursor for coenzymes involved in cellular energy metabolism.
• Vitamin B6 (Pyridoxine): Involved in amino acid metabolism and neurotransmitter synthesis.

Step 1: Matching Vitamin A (Vitamin B12) with its classic deficiency condition.
A severe deficiency of Vitamin B12 directly interferes with RBC production, causing the formation of large, immature, dysfunctional red blood cells. This condition is clinically termed Pernicious anaemia. Thus, A matches with IV.

Step 2: Matching Vitamin B (Vitamin D) with its structural skeletal disease.
Inadequate Vitamin D leads to poor bone mineralization. In growing children, this results in soft, weak, and deformed bones, a condition known as Rickets. Thus, B matches with III.

Step 3: Matching Vitamin C (Vitamin B2) with its localized mucosal symptom.
A deficiency in Riboflavin (Vitamin B2) characteristically causes inflammation and painful fissures or cracking at the corners of the mouth and lips. This clinical condition is called Cheilosis. Thus, C matches with I.

Step 4: Matching Vitamin D (Vitamin B6) with its neurological clinical symptom.
Inadequate levels of Pyridoxine (Vitamin B6) disrupt normal neurotransmitter synthesis, which can lead to localized central nervous system irritation and muscular convulsions, especially in infants. Thus, D matches with II. Combining all the individual pairings yields the complete matching pattern: A-IV, B-III, C-I, D-II, which corresponds perfectly to option (D).