Question

Match List I (Anticancer agent) with List II (Stages of cell cycle inhibition): [H] {|l|l|l|l|} \multicolumn{2}{|c|}{LIST-I & \multicolumn{2}{c|}{LIST-II
\multicolumn{2}{|c|}{Anti cancer agent & \multicolumn{2}{c|}{Stages
A. & Etoposide & I. & G1
B. & Hydroxyurea & II. & S
C. & Topotecan & III. & M
D. & Paclitaxel & IV. & G2

• A. A-I, B-III, C-II, D-IV
• B. A-I, B-II, C-IV, D-III
• C. A-II, B-III, C-I, D-IV
• D. A-IV, B-III, C-II, D-I

Hint:

Taxels (Paclitaxel) act on spindles, which only appear in the M phase!

Answer 1

The Correct Option is B

Step 1: Concept
Most anticancer drugs are cell-cycle specific, targeting cells at a particular stage of division.

Step 2: Meaning
Matching the drug to its phase of action helps in understanding the mechanism of cell death.

Step 3: Analysis
Etoposide (A) is specific to the $G_1$ (and $S$) phase. Hydroxyurea (B) inhibits DNA synthesis in the $S$ phase. Topotecan (C) typically acts at the $G_2$ phase. Paclitaxel (D) is a microtubule stabilizer that acts during Mitosis ($M$ phase).

Step 4: Conclusion
The correct matches are A-I, B-II, C-IV, D-III.

Final Answer: (B)