Question:
Match items in List-I with the items in List-II:
Match items in List-I with the items in List-II:
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Serology Timeline:
- Landsteiner (1900): ABO System
- Landsteiner & Levine (1927): MN System
- Levine & Stetson (1939): Rh antibody in human pregnancy
- Landsteiner & Wiener (1940): Rh antigen using Rhesus monkeys
- Landsteiner (1900): ABO System
- Landsteiner & Levine (1927): MN System
- Levine & Stetson (1939): Rh antibody in human pregnancy
- Landsteiner & Wiener (1940): Rh antigen using Rhesus monkeys
Updated On: Sep 4, 2026
- (A) - (II), (B) - (I), (C) - (IV), (D) - (III)
- (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
- (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
- (A) - (IV), (B) - (III), (C) - (II), (D) - (I)
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Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Concept:
Serological markers and polymorphic blood group systems are critical tools in physical anthropology and population genetics.
The discovery of erythrocyte antigens in the early 20th century laid the foundations of modern transfusion medicine and human diversity studies.
This question tests historical milestones in the discovery of major human blood group systems.
Step 1: Matching ABO and MN Blood Group Discoveries:
1. ABO System: Discovered by Austrian physician Karl Landsteiner in 1900--1901, who identified A, B, and O agglutinogens on red blood cells (awarded the Nobel Prize in 1930). Thus, (C) matches with (II).
2. MN System: Discovered in 1927 by Karl Landsteiner and Philip Levine through the immunization of rabbits with human red blood cells. Thus, (B) matches with (III).
Step 2: Matching Rh Factor Discoveries:
1. Rh in humans (Clinical Discovery): In 1939, Philip Levine and Rufus Stetson identified an antibody in a mother who delivered a macerated stillborn fetus, describing the clinical mechanism of maternal-fetal Rh incompatibility. Thus, (A) matches with (IV).
2. Rh in humans and Rhesus monkeys: In 1940, Karl Landsteiner and Alexander S. Wiener discovered the Rh antigen experimentally by testing rabbit antisera raised against Macaca mulatta (Rhesus monkey) blood against human erythrocytes. Thus, (D) matches with (I).
Step 3: Final Answer:
The matched pairs are:
(A) $\rightarrow$ (IV), (B) $\rightarrow$ (III), (C) $\rightarrow$ (II), (D) $\rightarrow$ (I).
This corresponds precisely to Option (D).
Serological markers and polymorphic blood group systems are critical tools in physical anthropology and population genetics.
The discovery of erythrocyte antigens in the early 20th century laid the foundations of modern transfusion medicine and human diversity studies.
This question tests historical milestones in the discovery of major human blood group systems.
Step 1: Matching ABO and MN Blood Group Discoveries:
1. ABO System: Discovered by Austrian physician Karl Landsteiner in 1900--1901, who identified A, B, and O agglutinogens on red blood cells (awarded the Nobel Prize in 1930). Thus, (C) matches with (II).
2. MN System: Discovered in 1927 by Karl Landsteiner and Philip Levine through the immunization of rabbits with human red blood cells. Thus, (B) matches with (III).
Step 2: Matching Rh Factor Discoveries:
1. Rh in humans (Clinical Discovery): In 1939, Philip Levine and Rufus Stetson identified an antibody in a mother who delivered a macerated stillborn fetus, describing the clinical mechanism of maternal-fetal Rh incompatibility. Thus, (A) matches with (IV).
2. Rh in humans and Rhesus monkeys: In 1940, Karl Landsteiner and Alexander S. Wiener discovered the Rh antigen experimentally by testing rabbit antisera raised against Macaca mulatta (Rhesus monkey) blood against human erythrocytes. Thus, (D) matches with (I).
Step 3: Final Answer:
The matched pairs are:
(A) $\rightarrow$ (IV), (B) $\rightarrow$ (III), (C) $\rightarrow$ (II), (D) $\rightarrow$ (I).
This corresponds precisely to Option (D).
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