Question

Large volume parenterals (LVPs) must be free from preservatives because _______

• A. They alter pH
• B. They cause precipitation
• C. Toxicity risk due to large dose
• D. They reduce sterility

Hint:

Large volume parenterals should not contain preservatives because large administered volume increases toxicity risk.

Answer 1

The Correct Option is C

Concept:
Large volume parenterals are sterile preparations administered in large volumes, usually by intravenous route.

Step 1: Understanding preservatives.
Preservatives are added to prevent microbial growth in some formulations.

Step 2: Why they are avoided in LVPs.
Since LVPs are administered in large quantities, even a small concentration of preservative can result in a significant total amount entering the body.

Step 3: Toxicity concern.
This may cause toxicity, especially because LVPs are given directly into systemic circulation.

Step 4: Final answer.
Therefore, LVPs must be free from preservatives due to toxicity risk from large dose. \[ \boxed{\text{Toxicity risk due to large dose}} \]