Question:

In the evidence based practice process, when one uses the PICO format, what does the C in PICO stands for or represents?

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PICO = Patient, Intervention, Comparison, Outcome C = Control/Comparison group
Updated On: May 22, 2026
  • Subject's health characteristics, age, lifestyle
  • Giving no intervention to a set of subjects
  • Giving intervention to a set of subject
  • Blood pressure measurement in hypertensives in a BP lowering effect of exercise study
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The Correct Option is B

Solution and Explanation

Concept:
PICO is a framework used in Evidence-Based Practice (EBP) to formulate clinical research questions. It helps in structuring and identifying relevant evidence efficiently. The components of PICO are:
P = Patient/Population/Problem
I = Intervention
C = Comparison (or Control)
O = Outcome

Step 1: Understanding the role of 'C'.

The letter C in PICO refers to:
• A comparison group
• A control group
• An alternative intervention or no intervention

Step 2: Interpretation of comparison group.

In clinical studies:
• One group receives the intervention
• The other group (comparison group) may:
• Receive no treatment
• Receive placebo
• Receive standard care

Step 3: Evaluating options.


• Option (1) → describes population
• Option (2) → describes control/comparison group (correct)
• Option (3) → describes intervention
• Option (4) → describes outcome

Step 4: Conclusion.

Thus, the correct meaning of 'C' is: \[ \boxed{\text{Comparison group (no intervention or alternative)}} \]
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