Question:

In the DNA molecule

Show Hint

Use the mnemonic: "Apple in the Tree, Car in the Garage."
A-T (Apple/Tree) and C-G (Car/Garage).
Also, remember that G-C pairs are stronger because they have 3 hydrogen bonds compared to the 2 bonds in A-T pairs.
  • Guanine pairs with thymine
  • Adenine pairs with thymine
  • Cytosine pairs with thymine
  • Adenine pairs with cytosine
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The Correct Option is B

Solution and Explanation

Step 1: Understanding the Question:
The question asks for the fundamental base-pairing rules (Chargaff's rules) that maintain the double-helix structure of DNA.
Detailed Explanation:

Complementary Base Pairing:
The two strands of DNA are held together by hydrogen bonds between specific nitrogenous bases.
A purine always pairs with a pyrimidine to maintain a constant width of the double helix.

Specific Pairs:
Adenine (A) pairs with Thymine (T): They form two hydrogen bonds.
Guanine (G) pairs with Cytosine (C): They form three hydrogen bonds.

Analyzing the options:
Option (A), (C), and (D) are incorrect because they suggest non-complementary pairings that do not occur in a standard B-DNA molecule.

Step 2: Final Answer:

In a DNA molecule, Adenine always pairs with Thymine via two hydrogen bonds.
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