Concept:
Odds against an event are:
\[
\text{unfavourable outcomes} : \text{favourable outcomes}
\]
ip
Step 1: Find favourable outcomes.
The event is that 4 or 5 turns up.
So favourable outcomes are:
\[
\{4,5\}
\]
Hence number of favourable outcomes:
\[
2
\]
ip
Step 2: Find unfavourable outcomes.
A die has 6 outcomes in total.
So unfavourable outcomes:
\[
6-2=4
\]
ip
Step 3: Write the odds against.
\[
\text{Odds against} = 4:2 = 2:1
\]
ip
Hence, the correct answer is:
\[
\boxed{(A)\ 2:1}
\]