Step 1: Find the first derivative.
We are given \( y = 3e^{5x} + 5e^{3x} \). First, compute the first derivative \( \frac{dy}{dx} \):
\[
\frac{dy}{dx} = 15e^{5x} + 15e^{3x}.
\]
Step 2: Find the second derivative.
Next, compute the second derivative \( \frac{d^2 y}{dx^2} \):
\[
\frac{d^2 y}{dx^2} = 75e^{5x} + 45e^{3x}.
\]
Step 3: Subtract \( 8 \frac{dy}{dx} \).
Now, subtract \( 8 \frac{dy}{dx} \) from \( \frac{d^2 y}{dx^2} \):
\[
\frac{d^2 y}{dx^2} - 8 \frac{dy}{dx} = (75e^{5x} + 45e^{3x}) - 8(15e^{5x} + 15e^{3x}) = -15(3e^{5x} + 5e^{3x}) = -15y.
\]
Step 4: Conclusion.
Thus, the correct answer is option (C), \( -15y \).