Concept:
The Complex Conjugate Root Theorem states that if a polynomial has real coefficients, then any complex roots must occur in conjugate pairs. Furthermore, for a quadratic equation $ax^2 + bx + c = 0$, the product of the roots is equal to $c/a$.
Step 1: Identify the nature of the coefficients.
The given quadratic equation is $x^2 - 4x + c = 0$.
We are told that $c$ is a real number. Since $1$, $-4$, and $c$ are all real coefficients, the Complex Conjugate Root Theorem applies.
Step 2: Determine the second root.
We are given that one root is $r_1 = 2 + i$.
Because complex roots must occur in conjugate pairs, the second root must be its conjugate:
$$r_2 = 2 - i$$
Step 3: Use the relationship for the product of roots.
For the standard quadratic equation $ax^2 + bx + c = 0$, the product of the roots $(r_1 \cdot r_2)$ equals $\frac{c}{a}$.
In our equation, $a = 1$. Therefore:
$$r_1 \cdot r_2 = \frac{c}{1} = c$$
Step 4: Calculate the product of the complex roots.
Multiply the two conjugate roots together using the difference of squares pattern $(A+B)(A-B) = A^2 - B^2$:
$$c = (2 + i)(2 - i)$$
$$c = 2^2 - (i)^2$$
Step 5: Evaluate the final value of c.
Remember that the imaginary unit squared is negative one ($i^2 = -1$).
$$c = 4 - (-1)$$
$$c = 4 + 1$$
$$c = 5$$
Hence the correct answer is (D) 5.