Question:
Glanzmann thrombasthenia is due to:
Glanzmann thrombasthenia is due to:
Updated On: Jul 14, 2025
- Decreased GpIb
- Decreased GpIIb/IIIa
- Anti-GpIIb/IIIa antibodies
- Inhibition or deficiency of ADAMTS 13
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The Correct Option is B
Solution and Explanation
Glanzmann thrombasthenia is a rare genetic platelet disorder characterized by a defect in platelet aggregation, which is essential for blood clotting. This condition is due to a deficiency or dysfunction of the glycoprotein complex GpIIb/IIIa on the surface of platelets.
The typical function of the GpIIb/IIIa complex is to bind fibrinogen and other adhesive proteins, facilitating platelet aggregation at sites of vascular injury. In individuals with Glanzmann thrombasthenia, the decreased availability of functional GpIIb/IIIa impairs this process, leading to increased bleeding tendency.
From the options provided:
| Option | Explanation |
| Decreased GpIb | Not responsible for Glanzmann thrombasthenia; associated with Bernard-Soulier syndrome. |
| Decreased GpIIb/IIIa | Correct answer; directly causes Glanzmann thrombasthenia. |
| Anti-GpIIb/IIIa antibodies | Not the cause of Glanzmann thrombasthenia; related to immune-mediated conditions. |
| Inhibition or deficiency of ADAMTS 13 | Related to thrombotic thrombocytopenic purpura, not Glanzmann thrombasthenia. |
Thus, the correct answer is Decreased GpIIb/IIIa.
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